Director / Senior Director, Lab-in-the-Loop

The posting, as Altos Labs wrote it

Our Mission

Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life.

For more information, see our website at altoslabs.com.

Our Value

Our Single Altos Value: Everyone Owns Achieving Our Inspiring Mission .

Diversity at Altos

Altos Labs has been named one of the Top 3 Biotech Companies and ranked for the second year on the Forbes 2026 Best Startups in America list. At Altos, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining a diverse and inclusive environment.

What You Will Contribute To Altos

The rate limit on ML for biology is rarely the model. It is the loop between what the lab measures and what the model needs. Altos is looking for a Director or Senior Director-level scientist to own that loop across in vitro and in vivo systems: closed-loop systems where predictions steer the next experiment and results retrain the model, and rigorous standalone verification of model outputs where the wet-lab design still has to hold up. As IoC's ML-for-biology programs scale, the loop between experimental design and model development becomes an increasingly critical driver of progress — the tighter that loop, the faster and more reliably we can improve both. We're looking for a leader who will push the envelope of the lab-in-the-loop with deep expertise in wet-lab biology and machine learning.

Responsibilities

• Lead a team responsible for closed-loop experimental systems that generate data purpose-built to train and validate large-scale foundation and hybrid models for biology.
• Lead experimental verification of model outputs that fall outside the tight iterative loop — for example, validating target hypotheses from the hybrid modeling program — ensuring these results are rigorous enough to inform go/no-go decisions even when they don't directly retrain a model.
• Partner directly with ML leads across multimodal predictive modeling, foundation model pretraining, and hybrid/mechanistic modeling efforts to ensure model outputs — including in silico perturbation predictions and target hypotheses — are experimentally testable, and that experimental results feed back efficiently to improve model performance.
• Architect and implement innovative experimental designs that target a ML-first data generation strategy: what to measure, at what scale and modality, to most efficiently reduce model uncertainty, verify and improve identifiability of hybrid/mechanistic models.
• Look strategically beyond current needs to identify and develop new in vitro and in vivo model systems required to meet the longer-term needs of IoC's models — treating the lab not just as infrastructure to operate, but as a lever for generating the most scientifi

[…]
0 - $335,300

• Senior Director $305,800- $392,100

Exact compensation may vary based on skills, experience, and location.

#LI-NN1

For UK applicants, before submitting your application

• Please click here to read the Altos Labs EU and UK Applicant Privacy Notice ( bit.ly/eu_uk_privacy_notice )
• This Privacy Notice is not a contract, express or implied and it does not set terms or conditions of employment.

Equal Opportunity Employment

We value collaboration and scientific excellence.

We believe that a culture of belonging are foundational to scientific innovation and inquiry. At Altos Labs, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining an inclusive environment.

Altos Labs provides equal employment opportunities to all employees and applicants for employment, without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. Altos prohibits unlawful discrimination and harassment. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Thank you for your interest in Altos Labs where we strive for a culture of scientific excellence, learning, and belonging.

Note: Altos Labs will not ask you to download a messaging app for an interview or outlay your own money to get started as an employee. If this sounds like your interaction with people claiming to be with Altos, it is not legitimate and has nothing to do with Altos. Learn more about a common job scam at https://www.linkedin.com/pulse/how-spot-avoid-online-job-scams-biron-clark/