Director/Senior Director, HEOR Modeling and Evidence Synthesis

The posting, as Axsome Therapeutics wrote it

Axsome Therapeutics is a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) conditions. We deliver scientific breakthroughs by identifying critical gaps in care and develop differentiated products with a focus on novel mechanisms of action that enable meaningful advancements in patient outcomes. Our industry-leading neuroscience portfolio includes FDA-approved treatments for major depressive disorder, agitation associated with dementia due to Alzheimer’s disease, excessive daytime sleepiness associated with narcolepsy and obstructive sleep apnea, and migraine, as well as multiple novel product candidates addressing a broad range of serious neurological and psychiatric conditions that impact over 150 million people in the United States. Together, we are on a mission to solve some of the brain’s biggest problems so patients and their loved ones can flourish. For more information, please visit us at www.axsome.com and follow us on LinkedIn and X .

About This Role

Axsome Therapeutics is seeking a Director/Senior Director, HEOR Modeling and Evidence Synthesis to serve as the company’s senior technical expert for health economic modeling and comparative evidence generation. Reporting to the Associate Vice President of Health Economics & Evidence Generation Strategy, this hands-on role will conceptualize, build, validate, interpret, and communicate fit-for-purpose models supporting marketed products and pipeline assets across rare and prevalent CNS conditions.

The Director/Senior Director will lead the scientific strategy and execution of cost-effectiveness, budget impact, disease, and other decision-analytic models; and lead systematic literature reviews, indirect treatment comparisons, and formal network meta-analyses. The individual will partner closely with HEOR Product Leads, HEOR Analytics, Medical Strategy, Market Access, Publications, and other cross-functional colleagues to translate clinical, epidemiologic, economic, and patient-centered evidence into decision-ready insights, payer-relevant materials, and high-quality scientific publications.

This role is based at Axsome’s HQ in New York City with an on-site requirement of at least three days per week. We are unable to consider candidates who are looking for fully remote roles.

Job Responsibilities and Duties include, but are not limited to, the following:

Economic Modeling Strategy and Execution

• Responsible for end-to-end development of health economic models, from conceptualization and technical specifications through programming, validation, adaptation, reporting, interpretation, and external communication in partnership with HEOR Product Leads and cross-functional stakeholders
• Design and develop fit-for-purpose models, including cost-effectiveness and cost-utility models, cost-consequence analyses, budget impact models, decision trees, cohort and patient-level state-transition models, partitioned-survival models, discrete-event si

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evidence requirements, AMCP dossiers, value communications, reimbursement and access environments, and relevant modeling and evidence-synthesis guidelines

• Experience designing or conducting analyses using administrative claims and/or electronic health records is a plus
• Excellent writing, presentation, and interpersonal skills, with the ability to translate complex methods, uncertainty, and tradeoffs into actionable recommendations for senior and cross-functional audiences
• Collaborative, adaptable, diplomatic, detail-oriented, and comfortable navigating ambiguity
• Launch and lifecycle-management experience is strongly preferred; neuroscience experience is preferred

Salary and Benefits

The anticipated salary range for this role is $220,000 - $285,000. The salary offer will be based on a variety of factors, including experience, qualifications, internal equity and location. Axsome offers a competitive employment package that includes an annual bonus, significant equity and a generous benefits package.

Axsome is committed to equal employment opportunity and providing reasonable accommodations to applicants with physical and/or mental disabilities. We value and encourage diversity and solicit applications from all qualified applicants without regard to race, color, gender, sex, age, religion, creed, national origin, sexual orientation, gender identity, ancestry, citizenship, marital status, physical or mental disability, medical condition, veteran status, genetic information, or any other characteristic protected by federal, state, or local law.

Axsome Therapeutics does not accept unsolicited resumes from recruiters or third-party recruitment agencies and will not pay placement fees for unsolicited candidates that are sent to hiring managers, the HR team or other Axsome team members. Only approved vendors who have been explicitly asked to support a specific search will receive access to our Applicant Tracking System to submit candidates for consideration.