Associate Director, LNP Manufacturing

The posting, as Flagship Pioneering, Inc. wrote it

Company Summary

Serif Biomedicines is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases.

Serif was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture.

Position Summary

We are seeking an outstanding Associate Director to join us in ideating and building the next generation of Programmable Medicines and lead a team of talented scientists and engineers. We’re looking for strong scientific leadership skills, a strong drive to innovate, and deep domain experience in lipid nanoparticle manufacturing and scale up . More broadly, we’re looking for an individual who brings scientific rigor, passion for leadership and mentoring of a diverse team, obsessive attention to detail, intellectual curiosity, enthusiasm, and a desire to innovate in a highly collaborative environment. This individual will have the opportunity to work in a dynamic and fast-paced entrepreneurial environment, working as part of a highly motivated and growing team.

Key Responsibilities

• Lead LNP scale-up from small R&D formulations to NHP scale in support of a development candidate. This merges the first bullet and the “ensure successful scale-up of drug product formulation and purification unit operations” bullet.
• Drive upstream and downstream process development , including mixing platforms (T-mix, impingement), TFF, and freeze/storage buffer optimization.
• Scale targeted LNPs (tLNPs) , including conjugation, purification, and associated analytics.
• Run micro- to mid-scale formulation on microfluidics platforms (e.g., NanoAssemblr) to support platform advancement alongside cross-functional partners.
• Integrate QC profiling and method development (DLS, HPLC/CAD, LC-MS, encapsulation distribution assays) into process development.
• Lead and mentor a team of scientists and engineers, and partner across departments to deliver for in vivo studies.

Qualifications

• Ph.D. in chemistry, chemical engineering, biochemistry, or biomedical engineering, plus relevant industry experience
• Hands-on experience scaling nucleic acid LNP formulations across upstream, downstream, and analytics
• Working knowledge of mixing platforms (T-mix, impingement, microfluidics) and TFF
• Familiarity with LNP analytical methods (DLS, HPLC/CAD, LC-MS, encapsulation assays)
• Solid understanding of lipid and LNP design principles, stability, and their impact on critic

[…]
atus, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

The salary range for this role is $154,000 - $203,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Serif Biomedicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Serif Biomedicines's good faith estimate as of the date of publication and may be modified in the future.

Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.