Director, Health Data Science

The posting, as Flagship Pioneering, Inc. wrote it

Who we are

FL113 is a fast-moving AI diagnostics company with a bold ambition: to define the future of pre-emptive and proactive care. We are building products that help uncover disease before it becomes visible, equip patients and care teams with earlier insight, and enable meaningful intervention before disease advances and causes irreversible harm. Our team brings together ML researchers, serial entrepreneurs, and clinical experts, united by a common commitment to make proactive care a reality.

FL113 is part of the Flagship Pioneering ecosystem, a premier venture-creation platform recognized twice on FORTUNE’s “Change the World” list and twice on Fast Company’s list of the World’s Most Innovative Companies. Flagship creates companies at the frontier of science and technology, bringing together founders, operators, and investors to take bold leaps on consequential problems and turn breakthrough ideas into enduring businesses. Join an exceptional team and help shape the future of AI and healthcare.

About the role

The Director of Health Data Science owns FL113’s scientific agenda, model methodology and performance, clinical validation, and evidence generation. You will determine which scientific questions to pursue, how to assess model performance and clinical utility, and what evidence is required to support product readiness, customer adoption, and regulatory strategy.

You will work closely with peer leaders across Engineering, Product, and GTM, as well as customers, health-system partners, and the broader Flagship ecosystem, to shape product development and delivery. You will retain accountability for scientific rigor, model performance, and real-world evidence. Research defines scientific requirements and acceptance criteria; Engineering owns production architecture, implementation, deployment, and operations. Together, we will use evidence from models, pilots, and customers to refine product-market fit and build products that earn trust in the real world.

Key Responsibilities

Set the Scientific Agenda

• Own and continuously evolve a multi-year research roadmap spanning predictive modeling, causal inference, and longitudinal analysis, informed by scientific, clinical, product, and market evidence.
• Translate the research roadmap into practical milestones, decision gates, and resource requirements.
• Exercise pragmatic scientific and product judgment, connecting model performance to clinical value, customer ROI, and development time.
• Define and uphold fit-for-purpose standards for data quality, model validation, study design, reproducibility, and responsible use of AI.
• Apply AI-enabled tools and agentic workflows to accelerate research, experimentation, analysis, and team productivity.

Lead Model Development and Validation

• Define the scope and design of research programs, including indication selection, data strategy, modeling approach, endpoints, and validation criteria.
• Oversee model development and validation ac

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work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.

The salary range for this role is $192,000 - $253,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. FL113 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL113's good faith estimate as of the date of publication and may be modified in the future.

Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.