Director, Pharmacology

The posting, as Flagship Pioneering, Inc. wrote it

What if you could join a rapidly growing company and play a critical role in bringing new medicines to patients through looking at and treating disease in a revolutionary way.

What this position is all about

What if you could join a fast-moving research organization and help shape translational strategy across a growing preclinical pipeline? Cellarity is seeking a highly strategic Sr. Director, Pharmacology to connect biology, pharmacology, DMPK, and translational science across inflammation and hematology programs. Reporting to the Sr. Director of Lab Science, this role will partner closely with biology, chemistry, DMPK, toxicology, external CROs, and scientific leadership to drive programs from early discovery through candidate selection.

What you would be responsible for

• Lead preclinical pharmacology strategy across multiple discovery programs, with a focus on translating in vitro biology and functional assay data into meaningful in vivo outcomes.
• Drive PK/PD interpretation, exposure-response assessment, target coverage analysis, and translational biomarker strategy to inform program decisions.
• Integrate data across biology, pharmacology, medicinal chemistry, and DMPK to build clear scientific narratives and guide candidate advancement.
• Oversee outsourced pharmacology studies and manage external CRO relationships to ensure studies are scientifically rigorous, well interpreted, and aligned to program objectives.
• Partner with internal scientific teams to define critical experiments, interpret data packages, and determine what additional studies are needed to advance programs with confidence.
• Provide strategic input to cross-functional program discussions from early discovery through candidate selection.
• Represent pharmacology at internal scientific and program meetings, communicating findings, risks, and recommendations with clarity and precision.
• Contribute to the development of broader translational approaches as the organization continues to expand its preclinical pipeline.

What experiences will you need

• PhD in biology, pharmacology, or a related scientific discipline, with 10-15+ years of relevant experience in biotech or pharmaceutical drug discovery and development.
• Strong foundation in preclinical pharmacology with demonstrated experience translating biology into in vivo efficacy and PK/PD insight.
• Experience connecting in vitro findings to in-vivo outcomes, including target engagement, exposure-response relationships, and translational biomarker strategy.
• Exposure to DMPK and ability to partner effectively with DMPK scientists on program interpretation and advancement.
• Proven track record of working across biology, chemistry, pharmacology, and external collaborators to influence drug discovery strategy.
• Experience managing and interpreting outsourced pharmacology studies through CROs.
• Strong scientific judgment, data integration skills, and the ability to build decision-enabling n

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, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies : Cellarity does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Cellarity or its employees is strictly prohibited unless contacted directly by Cellarity’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Cellarity, and Cellarity will not owe any referral or other fees with respect thereto.

The salary range for this role is $180,000 - $248,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Cellarity currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Cellarity's good faith estimate as of the date of publication and may be modified in the future.

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