Vice President, Translational Biology

The posting, as Flagship Pioneering, Inc. wrote it

COMPANY DESCRIPTION

Mirai Bio is a privately-held, Flagship-founded biotechnology company that is delivering genetic medicines from promise to performance. Mirai was built to solve one of the field’s central challenges: achieving precise, scalable delivery of diverse nucleic acid payloads to specific cells and tissues, particularly beyond the liver. By combining a large and growing proprietary in vivo biodistribution dataset, machine learning-guided lipid nanoparticle optimization, modular targeted particle design, and integrated translation and manufacturing capabilities, Mirai helps partners accelerate development, reduce technical risk, and pursue high-value programs making delivery a strategic advantage. We are seeking collaborative, relentless problem solvers that share our passion for defining the future of genetic medicines together.

THE ROLE

Mirai Bio is seeking a highly talented individual to lead its Translational Biology Group and manage multiple research programs as part of FL85’s Platform Group where they will identify, prioritize, and provide innovative solutions to challenges posed by delivery of nucleic acid therapeutics. They will work cross-functionally to direct and oversee discovery research and partner-based therapeutic candidate development programs to enable Mirai’s next generation genomic medicines. The successful candidate will implement strategies to overcome limitations of current nucleic acid delivery approaches and will have a strong understanding of targeted information molecule delivery and relevant in vitro and in vivo models. A robust background in immunology, pre-clinical pharmacology and in vivo delivery modalities is required. As the Head of Translational Biology , the successful candidate will support development of novel non-viral delivery capabilities and key responsibilities as below.

KEY RESPONSIBILITIES

• Directing and overseeing discovery programs covering in vitro and in vivo proof-of -concept studies in small and large animal models in support of developing innovative non-viral vectors with cell-specific tropism and/or enhanced functional delivery properties.
• Delivering rigorous workflows, including generation and implementation of ideas to facilitate novel non-viral delivery approaches with other parts of the organization and external collaborators.
• Designing and troubleshooting experiments derived from industry experience and literature review.
• Initiating and overseeing collaborations with industry partners with a view to helping them develop their therapeutic strategy.
• Establishing and managing timelines to ensure projects are completed according to schedule.
• Setting project priorities, planning workload, and managing resource and personnel scheduling.
• Ensuring group goals are met and are aligned with broader organizational objectives.
• Preparing study materials and presenting scientific presentations at internal and external meetings including to senior leadership.

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Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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The salary range for this role is $290,000 - $320,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Mirai Bio currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Mirai Bio's good faith estimate as of the date of publication and may be modified in the future.

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