Associate Director, Biotherapeutic Production and Characterization

The posting, as Generate Biomedicines wrote it

The Role

The Associate Director will lead a talented scientific team working at the intersection of biological engineering, protein science, automation, and data-enabled discovery. You will help define how difficult and diverse protein targets are designed, produced, characterized, and delivered to project teams with greater speed, scale, quality, and scientific insight, working at the intersection of biological engineering, protein science, automation, and data-enabled discovery. Your leadership will directly influence critical program decisions, the success of novel protein modalities in discovery, the technologies and capabilities we build, and the inclusive, high-performance culture we create.

At Generate:Biomedicines, this is an opportunity to combine deep experimental science with agentic design, automation, and high-throughput experimentation to tackle some of the most complex challenges in protein design and production. You will develop novel solutions for difficult-to-express antigens, membrane proteins, and other complex modalities, building workflows that connect sequence and structure to construct design, production, characterization, and scientific learning at scale.

As Associate Director, Biotherapeutic Production & Characterization, you will lead protein production, purification, and fit-for-purpose characterization in support of discovery and early development. You will be accountable for delivering high-quality, assay-ready protein reagents and actionable data that support critical program decisions, while advancing the technologies, data practices, and team capabilities needed to expand what we can design and produce.

Here's how you will contribute

• Oversee production across mammalian, bacterial, and cell-free systems, including end-to-end workflows for construct design, expression, purification, characterization, quality control, normalization, and assay-ready handoff.
• Drive innovation for difficult antigens and complex proteins through construct and boundary optimization, tag and format selection, alternate expression systems, site-specific labeling, automation, and other enabling technologies.
• Establish fit-for-purpose production, purification, and characterization standards for attributes including yield, purity, aggregation, concentration, identity, oligomeric state, stability, and biotinylation.
• Lead portfolio planning, prioritization, and resource allocation for the team across internal and outsourced production and characterization activities, balancing program delivery, platform advancement, capacity, timelines, and external spend.
• Manage relationships with CROs, technology providers, and other external partners, and communicate progress, risks, resource needs, and tradeoffs to senior stakeholders.
• Represent Biotherapeutic Production & Characterization on cross-functional program and platform teams, translating scientific objectives into actionable strategies and recommendations.
• Lead adop

[…]
pproach aims to reduce the uncertainty, time, and cost associated with developing protein-based medicines.

Founded in 2018, we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational design and clinical development within a single operating model, we translate this approach into clinical-stage programs and are leading a shift from traditional drug discovery toward systematic drug generation.

At Generate:Biomedicines, we collaborate across disciplines in new ways to invent and innovate. We bring diverse perspectives to a shared goal of delivering better medicines to patients in need, faster, guided by our values and leadership behaviors.

Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies : Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.

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Compensation: The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics. In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package.

Per Year Salary Range
$160,000 — $210,000 USD