Scientist II, Functional Bioassays & High Throughput Screening

The posting, as Generate Biomedicines wrote it

The Role

The Functional Bioassays team is seeking a Scientist II to develop, optimize, and execute functional assays across Generate’s therapeutic portfolio. This bench-focused role will generate high-quality data to guide protein design and program decisions, including AI/ML-enabled design cycles.

The scientist will design, optimize, and troubleshoot biochemical and cell-based assays; execute high-throughput screening campaigns; analyze results; and support automation integration across programs. Work may include ion-channel, GPCR, ADC-related, and other functional assay platforms as portfolio needs evolve.

Approximately 80–90% of this role will be laboratory-based. The scientist will collaborate with colleagues across Therapeutics, Technology, and cross-functional program teams to deliver well-controlled data for iterative design-build-test-learn cycles.

This role is suited to a hands-on scientist with experience in functional assay development and high-throughput screening who can take ownership of experiments, communicate results clearly, and adapt to changing program needs.

Here's how you will contribute

• Design, optimize, and implement high-throughput screening-compatible cell-based and biochemical assays, integrating automation where appropriate.
• Plan and execute plate-based high-throughput screening campaigns, analyze results, and interpret experimental datasets.
• Communicate findings to program teams to inform AI/ML-enabled design cycles, program decisions, and therapeutic optimization.
• Support high-throughput functional assay work across multiple therapeutic programs, with potential focus areas including ion channels, GPCRs, and ADC-related assays.
• Apply and expand expertise in novel functional assay technologies, including ion-channel and GPCR assays, as program needs evolve.
• Conduct experiments with attention to detail, scientific rigor, and adherence to established protocols.
• Troubleshoot assay performance, instrumentation, reagents, and workflows in partnership with senior scientists and Automation colleagues.
• Maintain accurate, timely, and well-organized records in electronic laboratory notebooks and other data systems.
• Prepare clear summaries of results for team discussions, program updates, and cross-functional meetings.
• Coordinate experiments with colleagues across Functional Bioassays, Automation, Biology, Protein Sciences, Data Science, and program teams.
• Follow laboratory safety practices, sample-handling requirements, data-integrity expectations, and Generate’s scientific standards.

The Ideal Candidate will have

• PhD in cell biology, pharmacology, immunology, biochemistry, bioengineering, molecular biology, or a related discipline, with approximately 2+ years of industry or postdoctoral experience; or MS with approximately 5+ years of relevant industry or academic research experience; or BS with approximately 7+ years of relevant industry or academic research experience.
• Hand

[…]
pproach aims to reduce the uncertainty, time, and cost associated with developing protein-based medicines.

Founded in 2018, we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational design and clinical development within a single operating model, we translate this approach into clinical-stage programs and are leading a shift from traditional drug discovery toward systematic drug generation.

At Generate:Biomedicines, we collaborate across disciplines in new ways to invent and innovate. We bring diverse perspectives to a shared goal of delivering better medicines to patients in need, faster, guided by our values and leadership behaviors.

Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies : Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.

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Compensation: The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics. In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package.

Per Year Salary Range
$114,000 — $150,000 USD