Senior Scientist I, Computational Protein Design

The posting, as Generate Biomedicines wrote it

The Role

Generate is seeking a creative and rigorous scientist to develop computational technologies and lead applied platform research that expand what protein therapeutics can do. You will develop reusable methods, scoring and evaluation tools, model benchmarks, agentic systems, and scientific workflows for protein design, engineering, and optimization. Your work will span creating new proteins, modifying existing molecules, and integrating molecular components to unlock new therapeutic applications.

At Generate, model development, protein design, high-throughput experimentation, structural characterization, and therapeutic development operate within one organization. This role offers the opportunity not only to advance computational methods, but to see them shape what proteins are built and tested, learn from rich in-house experimental data, and contribute to medicines in our pipeline. We are looking for someone who is motivated by both technical innovation and its application to drug development.

This role combines technology development with applied platform research. You will identify recurring scientific needs, lead research efforts, and turn successful approaches into durable capabilities with clear interfaces and validated performance. Working with program teams, biologists, and experimental scientists, you will test and refine these capabilities in relevant biological settings, establish proof of concept for new molecular properties and functions, and combine validated approaches to enable new therapeutic applications and pipeline programs. You will lead the computational research needed to establish feasibility, resolve technical risks, and make successful approaches reusable across targets and programs.

Here's how you will contribute

• Lead technology development and applied platform research. Identify high-value capability gaps and molecular or biological challenges, formulate testable hypotheses, and define research plans, milestones, and decision criteria. Drive projects from scientific question through computational implementation and experimental proof of concept to validated, reusable capabilities.
• Build and evaluate reusable protein engineering capabilities. Develop computational methods for protein design, optimization, and interaction modeling using generative, predictive, and biophysical approaches. Create scores and benchmarks to assess sequences, structures, biological functions, and developability. Define intended uses, interfaces, assumptions, and success criteria across targets, molecular formats, and therapeutic applications. Build reproducible datasets and evaluation protocols that reveal strengths and failure modes, quantify uncertainty, and guide appropriate use.
• Engineer and validate new molecular capabilities. Partner with assay, structural, and experimental scientists to design informative molecular libraries and iterative design–build–test–learn studies. Demonstrate control of properties such a

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, this approach aims to reduce the uncertainty, time, and cost associated with developing protein-based medicines.

Founded in 2018, we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational design and clinical development within a single operating model, we translate this approach into clinical-stage programs and are leading a shift from traditional drug discovery toward systematic drug generation.

At Generate:Biomedicines, we collaborate across disciplines in new ways to invent and innovate. We bring diverse perspectives to a shared goal of delivering better medicines to patients in need, faster, guided by our values and leadership behaviors.

Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies : Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.

Compensation: The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics. In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package.

Per Year Salary Range
$172,000 — $241,000 USD