Principal Scientist, Chemical Development

The posting, as Immunome, Inc. wrote it

Company Overview

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been accepted by the U.S. FDA; IM-1021, a clinical-stage ROR1 ADC; IM-1617, a clinical-stage solid tumor ADC; and IM-3050, a clinical-stage FAP-targeted radioligand therapy. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets.

Position Overview

We are seeking an experienced Principal Scientist, Chemical Development to join our dynamic team to help advance our pipeline of innovative targeted cancer therapies. The successful candidate will apply their expertise in small molecule process development and manufacturing to support a variety of modalities in the Immunome pipeline with a focus on small molecule linker-payload targets for ADCs. This person will play a key role in leading challenging drug candidate process development programs, enabling treatment of patients in need.

Responsibilities

Leadership

• Provide technical leadership as a key member of the chemical development team while maintaining alignment with the company's goals and objectives .
• Function as the technical lead on at least one program while also functioning as an individual technical contributor.
• Provide guidance and leadership to external partners working towards the successful advancement of antibody drug conjugates, radiopharmaceuticals, and other lead programs.
• Support programs at the bench as an individual contributor as needed.

Technical Expertise

• Leverage knowledge and experience in the development and execution of robust and scalable small molecule synthetic processes.
• Devise and evaluate alternative routes of synthesis with the aim of developing robust and efficient routes to APIs while reducing cost of goods (COGs) and shortening manufacturing lead times.
• Develop robust data packages for technical transfer of processes for manufacturing partners at external CMOs.
• Maintain knowledge of the current state of the art in synthetic methods utilized for the construction of complex molecules.
• Carry out thorough analytical data collection both as an individual contributor in the lab as well as via oversight and review of data collected at our external partners .
• Contribute to authoring relevant sections of various regulatory documents (IND, IMPD, NDA, briefing books, etc.) and provide SME support for related regulatory inquiries.

Cross-Functional Collaboration

• Execute the integrated CMC regulatory strategies for pipeline programs.
• Collaborate with research, regulatory affairs, and CMC teams to ensure seamless coo

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nd formulating presentations

• Ability to develop cross functional relationships with discovery chemistry and other pre-clinical groups.
• Experience in leading and managing technology transfers to third party process development and manufacturing partners.
• Knowledge of cGMP requirements and ICH guidelines related to CMC small molecule drug-substance development and manufacturing.
• Track record of working closely with cross-functional teams in a biopharmaceutical or pharmaceutical environment.
• Excellent interpersonal and communication skills.

Washington State Pay Range
$169,593 — $206,233 USD

Join Our Experienced, Passionate Team

Working at Immunome gives you the opportunity to make a difference in the lives of cancer patients, contribute to developing best-in-class targeted cancer therapies, and work with some of the brightest and most experienced minds in antibody-drug conjugate (ADC) development.

Immunome’s office is charged with the collective excitement and passion of people working together to develop life-changing cancer medicines. Our team thrives in an innovative, collaborative environment where employees are empowered to do their best work.

Immunome also offers a comprehensive benefit program for you and your family, including:

• Medical, dental, and vision insurance coverage for employees and their dependents, including 100% company-paid medical premiums for employees
• A 401(k) with employer match
• Employer-paid life insurance, short- and long-term disability insurance, and AD&D
• Paid time off, company holidays, and a week-long winter break between Christmas and New Years.
• Paid parental leave

E/E/O

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

E-Verify

Immunome, Inc. is a participant in E-Verify. Please review the following notices: E-Verify Participation Poster | Right to Work Poster (English) | Right to Work Poster (Spanish) .