Senior Director, Medical Affairs Operations

The posting, as Amylyx Pharmaceuticals wrote it

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).

Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.

The Opportunity

The Senior Director of Medical Affairs Operations will provide strategic and operational leadership for the Medical Affairs organization. This individual will be responsible for building and scaling the medical affairs operational infrastructure, processes, systems, governance, vendor ecosystem, budgets, and performance metrics necessary to support a high-performing and compliant medical organization.

Working closely with Medical Affairs leadership and cross-functional partners across Commercial, Regulatory Affairs, Clinical Development, Pharmacovigilance, Legal/Compliance, Market Access, and IT, the Senior Director will ensure operational launch readiness while establishing a foundation that can scale as the organization grows.

The successful candidate will be a proactive leader with deep expertise in medical affairs operations, launch planning, project management, vendor oversight, and process optimization in a fast-paced biotechnology environment.

Responsibilities

• Medical Affairs Strategic Operations: Partner with Medical Affairs leadership to develop annual strategic plans, budgets, resource and operating models, leadership team meeting agendas and governance structures, and organizational priorities to support launch readiness and operational excellence and efficiency.
• Launch Readiness and Execution: Ensure operational readiness for launch-related activities, including field medical effectiveness, medical information, publication and scientific communications, KOL engagement, and congress execution.
• Vendor and Budget Management: Oversee Medical Affairs budgets, forecasting, accruals, and financial planning. Partner with Finance and Procurement to optimize vendor and spending strategies. Lead selection, contracting, governance, and performance management of Medical Affairs vendors and strategic partners.
• Evidence Generation/Investigator-Initiated Research: Lead operational support for evidence-generation activities, including investigator-sponsored research, grants, collaborative research, and other applicable Medical Affairs studies. Establish governance, intake and review processes, contracting

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compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.

Base salary is one component of Amylyx’s total rewards package. In addition to competitive base pay, eligible employees may receive annual performance-based bonuses and equity awards, providing an opportunity to share in the company’s long-term success. Amylyx also offers a comprehensive benefits package designed to support the health, well-being, and financial security of our employees.

Estimated Pay Range
$281,000 — $316,000 USD

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Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know.

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