Director of IT

The posting, as BillionToOne wrote it

A Rare Opportunity to Shape the Future of Genomics

Join a team of brilliant, passionate innovators determined to transform healthcare. At BillionToOne, we've built a category-defining, publicly traded company on Nasdaq where transparency fuels trust, collaboration drives breakthroughs, and every contribution moves the needle on our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we build products that are 10x better than anything that exists today.

Our scientists, engineers, sales executives, and visionaries are united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion, and every innovation you contribute helps remove the fear of the unknown from some of life's most critical medical moments.

If you're driven by purpose, energized by innovation, and ready to help shape the future of precision medicine at scale, this is where you belong.

We are seeking a dynamic and experienced Director of IT to oversee and manage our Dev Ops and IT strategy. The ideal candidate will have a strong background in networking, infrastructure management, AWS cloud services and cybersecurity. This role will be pivotal in maintaining and enhancing our IT systems to support our business operations and growth. The Director of IT is a hybrid position (onsite 2-3 days per week) and reports to the VP of IT/IS.

Key Responsibilities

• IT Leadership and Strategy:
• Develop and implement IT strategies aligned with the company's scaling goals.
• Lead and manage the IT team, fostering a culture of excellence and continuous improvement.
• Oversee the design, implementation, and maintenance of the company's cloud infrastructure and set it up as a service for the organizations.
• Networking and Infrastructure:
• Ensure the reliability, security, and efficiency of our networking systems.
• Manage network configuration, performance monitoring, and troubleshooting.
• Oversee the setup, configuration, and maintenance of servers, storage, and other infrastructure components.
• Implement and manage disaster recovery and business continuity plans.
• AWS Cloud Management:
• Design and manage AWS cloud infrastructure, ensuring scalability, performance, and security.
• Oversee the strategy, deployment and management of AWS services, including EC2, S3, RDS, and VPC.
• Optimize cloud resources for cost-efficiency and performance.
• Implement and manage cloud security policies and procedures.
• Security and Compliance:
• Ensure IT security measures are in place and regularly updated to protect against data breaches and cyber threats.
• Ensure compliance with industry standards and regulations, including HIPAA, SOC 2 and other relevant guidelines.
• Conduct regular security audits and vulnerability assessments.
• Project Management:
• Lead IT projects from conception through completion, ensuring they are de

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BillionToOne is a next-generation molecular diagnostics company on a mission to make powerful, accurate diagnostic tests accessible to everyone. Our revolutionary QCT molecular counting technology enhances disease detection resolution by over a thousandfold using cell-free DNA,a breakthrough that has already transformed the lives of over half a million patients worldwide.

Our Impact

Unity Complete™ is the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample.
Unity Confirm™ enables non-invasive confirmation for high-risk screening results through the capture of intact circulating fetal cells using BillionToOne’s Fetal Cell Capture™ Technology.
Our Northstar® liquid biopsy test uniquely combines treatment selection with real-time monitoring, giving oncologists unprecedented precision in cancer care.

Our Growth

From $0 to $400M+ annualized revenue run-rate in just 6 years. In 2025, we completed one of the most successful IPOs for a medical diagnostics company, building on nearly $400M in private funding,including our $130M Series D in 2024 and backed by world-class investors including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest.

Our Recognition

Forbes named us one of America's Best Startup Employers for 2025 and we're Great Place to Work certified , with 100% of our people willing to go the extra mile, even as we've scaled to over 700 employees.

Our Future

Headquartered in Menlo Park with facilities in Union City, CA, and a new lab opening in Austin, TX in 2027, we're continuing to push the boundaries of what's possible in molecular diagnostics. We're just getting started.

Ready to help us change the world, one molecule at a time? Learn more at billiontoone.com