Director, Modeling and Simulation

The posting, as Flagship Pioneering, Inc. wrote it

What if... We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner?

About Flagship Pioneering

Flagship Pioneering is a scientific innovation engine that originates and builds platform companies and products that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps, exponentially accelerating scientific progress in human health, sustainability, and beyond. As part of our modeling and simulation team, you will partner across the Flagship ecosystem, from newly founded ventures to later-stage portfolio companies, applying mechanistic modeling approaches to help translate bold scientific ideas into transformative therapies.

Position Summary

We are seeking a highly motivated individual to provide leadership and hands-on support for modeling efforts (PK/PD/QSP) across Flagship’s diverse drug discovery portfolio. The qualified candidate is expected to support internal and external due diligence work, provide guidance for Flagship platform companies to accelerate timelines from Lead ID to DC and to apply innovative modeling approaches to inform early feasibility concepts. As programs advance, the role extends through Lead OP and pre-IND, integrating modeling workstreams into cross-functional development strategy and, in collaboration with clinical teams, supporting the design and interpretation of emerging clinical data. We are seeking individuals with deep subject matter expertise who are analytical, goal-oriented and committed to maintaining the highest scientific and ethical standards. Strong communication skills and comfort to utilize AI-supported modeling workflows in a dynamic, cross-functional team environment are highly desirable.

Key Responsibilities

• Work with cross-functional development teams and platform companies to identify modeling needs, model complexity and required data to
• help de-risk program questions related to safety and efficacy
• inform TCP and/or TPP
• provide guidance for pre-clinical in vitro and in vivo studies
• test MoA-related hypothesis
• conduct competitor analysis
• support clinical translation of pre-clinical data including FiH dose predictions
• inform target prioritization
• support regulatory interactions (e.g., FDA meetings, IND-enabling packages) through model-informed drug development (MIDD) approaches
• Develop QSP and PK/PD models (either internally or with CROs) for various modalities (small molecules, mono-clonal antibodies, multi-specifics, cell therapy, LNPs) and therapeutic areas (obesity, cardio-vascular, oncology, immunology, rare diseases)
• Provide guidance to early-stage Flagship companies to help accelerate their timelines from Lead ID to DC
• Utilize AI-supported modeling workflows to provide end-to-end modeling support including model scoping, model development, model calibration and

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materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.

The salary range for this role is $172,000 - $236,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.

Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.