Principal Scientist, Structural Biology / Protein Biophysics

The posting, as Flagship Pioneering, Inc. wrote it

Company Summary

Flagship Labs 132 (FL132) is an early-stage biotechnology company founded to address unmet need for patients with amyloidogenic diseases. This is a unique opportunity to be one of the first employees of a biotech startup that combines an innovative mindset with the resources and know-how of Flagship Pioneering. This is a hands-on role with significant responsibility for a scientist who is excited to set technical direction from day one and, over time, help build the team.

FL132 is backed by Flagship Pioneering, a company that invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since 2000, Flagship has originated and fostered the development of more than 100 scientific ventures advancing human health and sustainability, including Moderna, Generate Biomedicines, and Alltrna.

Position Summary

We are seeking a motivated, highly collaborative, and technically versatile Principal Scientist to help build FL132’s amyloid research platform from the ground up. This is a hands-on role at the interface of protein biophysics, chemical biology, structural biology, and drug discovery: producing assay-grade amyloid proteins, developing and qualifying rigorous aggregation and structural assays, and characterizing amyloid aggregates to advance therapies for amyloidogenic diseases. The successful candidate will have a strong track record of scientific and technical innovation, deep quantitative rigor, the drive to set technical direction from day one, and build company culture.

Key Responsibilities

• Contribute to scientific and technical direction in collaboration with FSP leadership to shape company strategy. We are looking for someone who thinks critically and wants to lead the efforts to build experimental methods and train the growing team.
• Establish in-house production and quality control of assay-grade recombinant amyloid proteins including seed-free monomer preparation and characterization.
• Design and analyze amyloid aggregation experiments including kinetic measuring amyloid aggregation.
• Characterization of amyloid aggregates via mass spectrometry, NMR, AFM, or related methods.
• Support the build of cell-based assays for evaluating amyloid toxicity, seeding, and clearance.
• Evaluate inhibitors of amyloid aggregation and translate findings from biochemical systems into cellular models.
• Scope, contract, and manage CROs and academic collaborations by establishing best experimental and documentation practices.
• Drive key project goals , ensure rapid, accurate turnaround of data and translate experimental results into insights presented at team meetings.

Required Qualifications

• PhD. in structural biology, chemical biology, biochemistry, biophysics, physical chemistry, or a related field, with 8+ years of relevant industry or postdoctoral experience.
• Hands-on recombinant protein expression, purification, and QC ideally wi

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The salary range for this role is $163,000 - $214,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. FL132 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL132's good faith estimate as of the date of publication and may be modified in the future.

Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.