Associate Director, Toxicology

The posting, as Parabilis Medicines wrote it

About Parabilis Medicines

Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines for patients with serious diseases by unlocking biologically important targets long considered undruggable. The company has pioneered a new class of alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that have historically been beyond the reach of conventional medicines. The company’s lead investigational medicine, zolucatetide, is the first and only direct inhibitor of the β-catenin:TCF interaction, a central node in the Wnt/β-catenin pathway that has eluded drug developers for decades. Zolucatetide is being evaluated in the clinic across multiple Wnt/β-catenin-driven diseases, including desmoid tumors, familial adenomatous polyposis (FAP) and a range of other solid tumor indications. Beyond zolucatetide, Parabilis is advancing additional Helicon-based programs focused on other challenging targets where we believe our medicines could have life-altering impact. For more information, visit www.parabilismed.com or follow us on LinkedIn .

What's the opportunity?

Parabilis Medicines is seeking a highly motivated and driven Associate Director, Toxicology to lead nonclinical safety programs across a diverse pipeline built on Parabilis’ clinically validated Helicon™ pipeline. This is a hands-on scientific leadership role embedded in the discovery and early development organization, with accountability for advancing candidates from lead optimization through IND filing and beyond. The successful candidate will serve as the nonclinical safety lead on cross-functional project teams, working autonomously to define strategy, drive execution, influence candidate selection, and ensure robust safety assessment across our pipeline.

Discovery-Stage / IND-Enabling Safety Engagement

• Partner with discovery teams during Pre-LO/LO to identify safety liabilities, design early safety profiling studies, and guide candidate selection through science-based risk assessment.
• Serve as the primary toxicology lead on project teams, driving alignment across multiple Research and Clinical functions to ensure integrated and timely IND readiness. Develop and communicate candidate-specific toxicology risk assessments and go/no-go recommendations to project teams and leadership.
• Apply knowledge of injectable formulations (subcutaneous, intravenous, intramuscular) to anticipate and address local tolerance, excipient toxicity, and route-of-administration-specific safety considerations.
• Design and oversee the complete IND-enabling nonclinical safety package, including acute and repeat-dose toxicology, safety pharmacology, genotoxicity, and local tolerance studies, across relevant species.
• In collaboration with project team, select appropriate species, routes of administration, doses, and study durations based on scientific rationale and regulatory expectations
• Author and own nonclinical sections

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travel up to 15%.

Core Values

Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Growth-Minded . We’re inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.
• In(ter)dependent. We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.
• Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• All-In. We’re All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.

The base salary range for this position is $170,000-$210,000 per year, depending on experience, qualifications, and internal practices. Parabilis’s total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees’ overall well-being.

As an equal opportunity employer, Parabilis Medicines values an inclusive workplace and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive | Cambridge, MA 02140 | www.parabilismed.com