Director, Discovery DMPK

The posting, as Parabilis Medicines wrote it

About Parabilis Medicines

Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines for patients with serious diseases by unlocking biologically important targets long considered undruggable. The company has pioneered a new class of alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that have historically been beyond the reach of conventional medicines. The company’s lead investigational medicine, zolucatetide, is the first and only direct inhibitor of the β-catenin:TCF interaction, a central node in the Wnt/β-catenin pathway that has eluded drug developers for decades. Zolucatetide is being evaluated in the clinic across multiple Wnt/β-catenin-driven diseases, including desmoid tumors, familial adenomatous polyposis (FAP) and a range of other solid tumor indications. Beyond zolucatetide, Parabilis is advancing additional Helicon-based programs focused on other challenging targets where we believe our medicines could have life-altering impact. For more information, visit www.parabilismed.com or follow us on LinkedIn .

What’s the opportunity?

Parabilis Medicines’ Drug Metabolism and Pharmacokinetics (DMPK) team is seeking an experienced Director-level scientist to provide strategic and scientific leadership across our portfolio of innovative peptide therapeutics. Reporting to the VP of Discovery DMPK, you will serve as a senior DMPK leader and primary representative across cross-functional discovery project teams, shaping DMPK strategy, play a key role in building an AI native organization and influencing key program decisions. You will partner closely with medicinal chemists, pharmacologists, toxicologists, and external CRO partners to integrate ADME, PK, and PK/PD insights, proactively identify and mitigate development risks, and advance novel therapeutics from early discovery through development candidate nomination.

Key responsibilities

• Provide strategic leadership for peptide DMPK across multiple discovery programs, establishing ADME strategy and ensuring alignment with program milestones, development objectives, and broader portfolio priorities.
• Lead the design, interpretation, and integration of in vitro and in vivo ADME/PK studies to drive lead optimization, development candidate nomination, and progression into IND-enabling development.
• Serve as a DMPK subject matter expert and strategic partner to medicinal chemistry, pharmacology, toxicology, and other cross-functional functions, integrating DMPK data to influence chemical design and prioritize novel chemical matter with favorable drug-like and translational properties.
• Identify and proactively address key DMPK risks, knowledge gaps, and development challenges, establishing fit-for-purpose strategies to enable program progression.
• Provide scientific oversight of external CROs and partners, ensuring high-quality execution of DMPK studies within program timelines and budgets.
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ct and leadership meetings.

Core Values

Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Growth-Minded . We’re inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.
• In(ter)dependent. We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.
• Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• All-In. We’re All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.

The base salary range for this position is $210,000-$250,000, depending on experience, qualifications, and internal practices. Parabilis’s total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees’ overall well-being.

As an equal opportunity employer, Parabilis Medicines values an inclusive workplace and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive | Cambridge, MA 02140 | www.parabilismed.com