Senior Scientist, Clinical Biomarkers - Oncology

The posting, as Parabilis Medicines wrote it

About Parabilis Medicines

Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines for patients with serious diseases by unlocking biologically important targets long considered undruggable. The company has pioneered a new class of alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that have historically been beyond the reach of conventional medicines. The company’s lead investigational medicine, zolucatetide, is the first and only direct inhibitor of the β-catenin:TCF interaction, a central node in the Wnt/β-catenin pathway that has eluded drug developers for decades. Zolucatetide is being evaluated in the clinic across multiple Wnt/β-catenin-driven diseases, including desmoid tumors, familial adenomatous polyposis (FAP) and a range of other solid tumor indications. Beyond zolucatetide, Parabilis is advancing additional Helicon-based programs focused on other challenging targets where we believe our medicines could have life-altering impact. For more information, visit www.parabilismed.com or follow us on LinkedIn .

What’s the opportunity?

We are seeking a Senior Scientist, Clinical Biomarkers to execute biomarker strategies that carry our oncology programs from pre-IND through Phase 1/2 clinical trials. In this role, you will translate preclinical biomarker findings into clinically feasible strategies, select and qualify fit-for-purpose assays, and drive hypothesis-driven data analysis and interpretation to inform patient selection, mechanism of action, and response monitoring. You will collaborate closely with Data Science, Biology, Clinical Science, Clinical Operations, Clinical Pharmacology, to translate biological insights into actionable clinical decisions and external engagement (e.g., with investigators and partners).

This is an individual-contributor role well suited to a scientist who is ready to apply their preclinical translational background to clinical biomarker work, with support from senior team members and cross-functional partners including Clinical Science, Clinical Operations, and Clinical Pharmacology. In this role, you will have the opportunity to shape biomarker strategy across a growing oncology pipeline.

Key Responsibilities

• Capture key biomarkers identified in preclinical studies and assess their feasibility for clinical translation, from pre-IND through Phase 1/2 programs
• Develop or qualify and implement fit-for-purpose clinical biomarker assays and vendors, setting expectations for anticipated data readouts, interpretation, and delivery timelines
• Conduct hypothesis-driven analysis, interpretation, and presentation of clinical biomarker data in support of clinical decision-making and external engagement
• Establish and maintain strong collaborative relationships with Data Science and Biology colleagues to perform exploratory biomarker analysis and support novel biomarker identification
• Partner with Clinical Scie

[…]
I is a strong plus

Core Values

Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Growth-Minded . We’re inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.
• In(ter)dependent. We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.
• Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• All-In. We’re All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.

The base salary range for this position is $140,000-$165,000 per year, depending on experience, qualifications, and internal practices. Parabilis’s total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees’ overall well-being.

As an equal opportunity employer, Parabilis Medicines values an inclusive workplace and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive | Cambridge, MA 02140 | www.parabilismed.com