Senior Scientist, Systems Integration

The posting, as Quantum-Si wrote it

Quantum-Si is seeking a Senior Systems Integration Scientist to drive integration, characterization, and troubleshooting for Proteus, our next-generation single-molecule protein sequencing platform. This role investigates performance issues across samples, reagents, surface chemistry, consumables, fluidics, instrumentation, and sequencing workflows. The successful candidate will use hands-on experimentation, statistical design, root-cause analysis, and system-level thinking to improve product performance, reproducibility, robustness, and customer readiness.

As part of our team, your core responsibilities will be:

Scientific Systems Integration and Characterization

• Design and execute system-level studies to identify critical parameters, interaction effects, operating ranges, and sources of variability across samples, reagents, surface chemistry, consumables, materials, fluidics, instrument conditions, and sequencing workflows.

Surface Chemistry and Material Interface Characterization

• Investigate surface and material interactions affecting sample loading, biomolecule immobilization, reagent activity, background, signal quality, and sequencing performance.
• Partner with Surface Chemistry and Consumables teams to characterize material compatibility, adsorption, contamination, surface variability, and manufacturing or environmental effects and translate findings into product improvements.

Reagent and Sample Stability

• Design and execute on-board, off-board, accelerated, and stress studies to characterize sample and reagent stability under customer-relevant storage and operating conditions.
• Identify degradation mechanisms and establish scientifically supported storage, handling, hold-time, and operating recommendations while differentiating sample, reagent, consumable, chip, surface, and instrument effects.

Experimental Design and Statistical Analysis

• Design statistically rigorous experiments, including multifactor DOE, with appropriate controls and acceptance criteria to identify critical variables, interaction effects, failure thresholds, and optimal operating conditions.
• Analyze complex experimental and sequencing datasets using JMP, Python, R, MATLAB, or equivalent tools and clearly communicate performance trends, variability, scientific risk, conclusions, and recommendations.

Cross-Functional Scientific Leadership

• Lead cross-functional investigations with Surface Chemistry, Reagent Development, Applications, Consumables, Engineering, Software, Quality, Manufacturing, Operations, and Customer Success, translating system-level observations into focused studies, integration strategies, and evidence-based conclusions.

Test Method and Protocol Development

• Develop reproducible experimental protocols, characterization plans, test methods, controls, acceptance criteria, analysis methods, and troubleshooting workflows that support rigorous investigations and defensible technical conclusions.

System Verificatio
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evelopment organization, or cross-functional matrix environment.

Compensation and Benefits

The estimated base salary range for this position in the United States is $135,000 - $155,000. In addition to base salary, full-time employees are eligible to participate in Quantum-Si's discretionary annual bonus program and may receive equity awards as part of the total compensation package. Actual compensation will be determined based on a variety of factors, including, but not limited to, the position level, relevant skills, knowledge, experience, qualifications, geographic location, internal equity, and market data.

Quantum-Si also offers a competitive benefits package designed to support employees' health, well-being, work-life balance, and family needs. Benefits include:

• Comprehensive medical, dental, and vision insurance coverage
• Health Savings Account (HSA) and Flexible Spending Account (FSA) options, where applicable
• Company-paid life and accidental death & dismemberment (AD&D) insurance
• Short-term and long-term disability coverage
• Employee Assistance Program (EAP) resources to support personal and professional well-being
• Discretionary paid time off and company-paid holidays
• Parental leave to support employees welcoming and caring for a new child
• 401(k) retirement savings plan with both pre-tax and Roth contribution options

Additional Information

Candidates must be authorized to work in the United States. Quantum-Si does not provide employment-based immigration sponsorship of any kind for this position, including support for applicants currently pursuing permanent residency (Green Card sponsorship).

Quantum-Si does not accept unsolicited agency resumes.

Quantum-Si is an E-Verify and equal opportunity employer regardless of race, color, ancestry, religion, gender, national origin, sexual orientation, age, citizenship, marital status, disability or Veteran status. All your information will be kept confidential according to EEO guidelines.