Senior Director, Global Commercial Development

The posting, as Revolution Medicines wrote it

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.

The Opportunity

Reporting to the Executive Director, Global Commercial Development – Pancreatic Cancer, this role will lead global commercial strategy and lifecycle development for the pancreatic cancer portfolio. This job description is across numerous positions, including daraxonrasib and zoldonrasib and future pipeline candidates, supporting opportunities in first-line metastatic, locally advanced, perioperative, and adjuvant disease, as well as future indications. This leader will translate evolving clinical evidence, patient and biomarker insights, and competitive dynamics into integrated global commercial strategies, portfolio investment recommendations, and stage-appropriate launch readiness. The role requires strong cross-functional leadership and close alignment with existing asset and indication teams.

Specifically, you will be responsible for

Own integrated pancreatic portfolio strategy: Lead global commercial development across therapeutic and pancreatic cancer settings; connect indication strategies to overall portfolio value.

Guide indication and lifecycle prioritization: Evaluate clinical and commercial opportunities, unmet need, competitive differentiation, treatment sequencing, and investment trade-offs; present clear recommendations for development and governance decisions.

Build treatment-setting strategies: Develop differentiated commercial hypotheses for first-line treatment, locally advanced disease, surgical/perioperative pathways, and adjuvant therapy, recognizing distinct patient journeys, customers, and evidence requirements.

Integrate asset and combination positioning: Partner with relevant product teams to shape complementary daraxonrasib and zoldonrasib strategies, including biomarker-defined populations, potential combination approaches, and implications of future portfolio evolution.

Lead patient and market forecasting: Develop global epidemiology, treatment-flow and patient-segmentation models, revenue scenarios, sensitivity analyses, and commercial value assessments across the continuum of pancreatic cancer care.

Shape clinical development through a commercial lens: Collaborate with Clinical Develop
[…]
anges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy . For additional information, please contact privacy@revmed.com .

Base Pay Salary Range
$232,000 — $290,000 USD

We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.

Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address.

If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to careers@revmed.com so we can share these impersonations with our IT team for tracking and awareness.