Senior Director, Head of Structural Biology

The posting, as Revolution Medicines wrote it

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.

The Opportunity

We are seeking a Senior Director, Head of Structural Biology, to lead the scientific strategy, team development, and operations of our Structural Biology group. The group integrates X-ray crystallography, NMR, and cryo-EM to advance oncology drug discovery through Revolution Medicines’ tri-complex molecular glue platform. You will partner closely with medicinal and computational chemistry to guide compound design and optimization, and with project teams and biologists to address structure-function relationships and mechanisms of action. Beyond individual programs, you will define the next stage of our structural biology capabilities, identifying the technologies, talent and external partnerships that will most improve discovery decisions and extend the reach of the platform. You will shape how we understand and design compound-induced protein interactions, translating molecular recognition and cooperativity and conformational dynamics into better molecules and new therapeutic opportunities for patients. This role combines deep scientific judgment with strategic leadership, cross-functional influence, and accountability for group performance and resources.

Responsibilities

Set and execute the Structural Biology strategy in partnership with research leadership, aligning near-term program needs and long-term capability development with portfolio and platform priorities.

Lead and develop a high-performing team of scientists across crystallography, NMR, and cryo-EM; establish clear expectations, provide coaching, and support career growth.

Partner with medicinal, computational, and digital discovery scientists to integrate experimental structures, predictive models, and molecular simulations into actionable hypotheses that guide molecular design, structure-activity relationship interpretation, compound optimization, and experimental validation, with appropriate assessment of confidence and risk.

Work closely with project teams and the Structural Biology group to define structure-function questions and design integrated studies with biochemistry, biophysics, and cellular biology that test mechanistic hypotheses and inform progra
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anges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

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Base Pay Salary Range
$244,000 — $305,000 USD

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