Executive Business Director, West

The posting, as Xenon Pharmaceuticals wrote it

Who We Are

Xenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do

We are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we submitted a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role

We are seeking a dynamic, patient-centric, strategic, collaborative, agile, and results-oriented Executive Business Director (EBD), Epilepsy to lead our West region. This leader will be responsible for leading and developing a team of Regional Sales Managers and ensuring successful execution of Xenon's commercial strategy across a multi-state geography. Reporting to the Vice President, Sales, the ABD serves as the senior field leader within the assigned area and is accountable for launch readiness, business performance, leadership development, field effectiveness, and cross-functional execution.

As Xenon prepares for its first commercial launch, the ABD will play a critical role in building the field organization, developing frontline leadership capabilities, establishing performance expectations, and ensuring consistent execution across all regions. The ABD
[…]
strongly preferred.

• Proven success building, developing, and leading high-performing organizations and leadership teams.
• Strong experience working with academic institutions, epilepsy centers, health systems, integrated delivery networks, and specialty markets.
• Demonstrated ability to influence and lead within complex matrix organizations.
• Strong strategic thinking, business planning, analytical, coaching, and organizational leadership capabilities.
• Excellent communication, collaboration, and cross-functional leadership skills.
• Proficiency with CRM platforms, analytics tools, and Microsoft 365 applications.
• Ability to travel up to 75%.
• Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans
• Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies
• Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices
• Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any
• Some international travel may be required

Other duties as assigned

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.