Principal Engineer, Enterprise Data Integration / Associate Director

The posting, as Xenon Pharmaceuticals wrote it

Who We Are

Xenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do

We are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we submitted a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role

We are seeking a Principal Engineer, Enterprise Data Integration, to join our Information Technology (IT) team. The position will help lead the design, implementation, and ongoing operation of Xenon’s enterprise integration, middleware, and data engineering capabilities. This individual will partner with leaders across IT, Commercial, Medical, Finance, Supply Chain, Clinical Development, Research, and Quality, and external partners to establish scalable, secure, and compliant data flows across Xenon’s enterprise application and analytics ecosystem.

This role will be a key enabler of Xenon’s growth and commercialization readiness, helping connect core platforms such as ERP, CRM, data warehouse, master data management, clinical and research systems, quality systems, and external partner networks. The successful candidate will combine strong hands-on technical d
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platform implementation experience is an asset.

• Experience integrating enterprise SaaS platforms and life-sciences systems such as ERP (Oracle Fusion or SAP S/4HANA), Veeva, Workday/HCM, CLM, Concur, Adaptive Planning, ServiceNow, eQMS, LIMS, EDC, ELN, clinical data repositories, or commercial data platforms.
• Experience with Computer Systems Assurance, GxP systems validation, SDLC, 21 CFR Part 11, HIPAA, GDPR, SOX, audit trails, data integrity, and role-based access controls is preferred.
• Ability to balance strategic architecture with pragmatic delivery in a growing, fast-paced organization; comfortable building capability, standards, and operating models from the ground up.
• Experience managing external consultants, implementation partners, managed service providers, and/or application service providers.
• Excellent communication and coordination skills across business, technical, Quality, Security, and vendor teams.
• Ability to manage multiple priorities, lead through ambiguity, and drive decisions with appropriate documentation and stakeholder alignment.
• Strong problem-solving skills, attention to detail, and ability to simplify complex technical concepts for non-technical audiences.
• Project management experience; Agile, PMP, ITIL, cloud, data, or integration platform certifications are a plus.

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.