Vice President, Clinical Development (Pain)

The posting, as Xenon Pharmaceuticals wrote it

Who We Are

Xenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do

We are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we submitted a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role

We are seeking a Vice President, Clinical Development (Pain) to join our team. The Vice President, Clinical Development for Pain will lead all aspects of the development of the company’s pain programs, including the current Phase 2 and future Phase 3 programs across both the Kv7 agonist and Nav 1.7 inhibitor programs. The Vice President, Clinical Development will be responsible for therapeutic development expertise in pain and will establish and maintain relationships with key internal stakeholders across the organization, including, but not limited to Biostatistics, Data management, Pharmacovigilance and Drug Safety, Trial Operations, Medical Writing, Regulatory, Quality, Medical Affairs and Commercial and key external stakeholders, including Clinical Research Organizations (CROs), key opinion leaders (KOLs), and Health Authorities.

This position reports to
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and efficacy

• Broad experience in clinical trial designs (Phases 1 to 3) implementation, execution, and clinical data interpretation
• Training in GCP and knowledge of the research process, of the importance of adherence to protocols, and of the accuracy needed in collection and documentation of research data
• Understanding of clinical trial operations, biostatistics, and data management techniques
• Good understanding of clinical pharmacology principles
• Working knowledge of health authority regulations regarding the evaluation and approval process
• Ability to engender credibility and confidence within and outside the company through scientific acumen and leadership skills; must have outstanding executive presence
• Be science and data driven
• The ability to work as part of a small team, both in a leadership role and as a contributing member is essential
• Adherence to the highest ethical standards
• Effective communicator with strong written and verbal communication skills
• Creative problem-solving skills
• Flexibility of thought and an openness to new ideas
• The ability to motivate and maintain a positive work environment is vital
• Strong team organization and delegation skills, promotes cooperation amongst the staff and resolve conflicts in a manner which encourages good work relations

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.