Lead Bioinformatics Scientist (Oncology)

The posting, as Natera wrote it

Natera is seeking a Lead Bioinformatics Scientist to join our Oncology Bioinformatics team and support the development, validation, and clinical application of our NGS-based assays. The ideal candidate has a strong background in data analysis for wet lab support and extensive experience with NGS data, with a focus on building solutions for oncology applications. In this role, you will shape the analytical validation strategy for an NGS assay, design and analyze feasibility and performance evaluation studies, and generate real-world evidence demonstrating its clinical utility. You will work with interdisciplinary teams to turn complex, multi-source data into actionable recommendations, supporting research, product development, validation, regulatory submissions, clinical studies, and scientific publications.

PRIMARY RESPONSIBILITIES

• Lead the analytical validation strategy for an NGS-based assay, including designing, analyzing, and troubleshooting feasibility and performance evaluation studies (e.g., PPA and LoD) with bench scientists and biostatisticians.
• Drive real-world evidence (RWE) studies that demonstrate the clinical utility of for therapy selection and patient management, from cohort selection through analysis of plasma mutation calls.
• Build rapid prototypes and pipelines for custom analyses that integrate data from multiple Natera products.
• Develop algorithms and tools to support new products, including contributions to the production bioinformatics pipeline.
• Act as an internal technical consultant on bioinformatics methodology for other functional groups.
• Work closely with assay development, engineering, biostatistics, clinical, commercial, regulatory, and lab operations teams.
• Contribute to regulatory submissions, clinical study reports, and scientific publications.

QUALIFICATIONS

• Master’s degree in bioinformatics (or a related field) with 10 years of post-graduate experience, or PhD with 4 to 8+ years of post-graduate experience (preferred).

KNOWLEDGE, SKILLS, AND ABILITIES

• Expert knowledge of bioinformatics tools for NGS, including sequencing QC and secondary analysis such as variant calling.
• Experience with WES/WGS/targeted sequencing of tissue and cfDNA, and with somatic variant calling (SNVs, indels, CNVs, fusions) on these data.
• Working knowledge of statistical methods for assay performance evaluation, and ability to collaborate with biostatisticians on study design.
• Strong programming and scripting skills in Python, R, and shell.
• Fluency in exploratory data analysis and visualization of complex datasets, with the ability to distill observations into actionable recommendations.
• Deep understanding of NGS workflows from sample extraction to sequencing, and the ability to link bioinformatic findings to wet lab root causes.
• Ability to communicate effectively with wet lab groups and cross-functional partners, and to explain technical concepts clearly.
• Ability to work independent

[…]
s include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

For more information, visit www.natera.com .

Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.

All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.

If you are based in California, we encourage you to read this important information for California residents.

Link: https://www.natera.com/notice-of-data-collection-california-residents/

Please be advised that Natera will reach out to candidates with a @ natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.

For more information

• BBB announcement on job scams
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