Associate Director, Computational Chemistry

The posting, as Revolution Medicines wrote it

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.

The Opportunity

We are seeking an accomplished and creative Associate Director to join our Computational Chemistry team, reporting to the Head of Computational Chemistry. A core priority of this role is to lead computational support for drug discovery programs, using structure-based drug design to guide compound design and optimization from hit finding through lead optimization. The Associate Director will also lead CompChem’s contribution to TQ, setting computational priorities, coordinating work across TQ efforts, and guiding scientific decisions.

As a leader within our Computational Chemistry team, you will:

Serve as a computational chemistry lead on multidisciplinary discovery teams, shaping project direction and compound design from hit finding through lead optimization. Integrate SAR, structural, biophysical, biochemical, and ADME/PK data to guide prioritization of Ro5 and bRo5 molecules.

Lead CompChem’s contribution to TQ, translating discovery strategy into computational objectives, work plans, and milestones. Coordinate execution across TQ efforts and be accountable for the quality, timeliness, and scientific impact of the work.

Partner with medicinal chemistry, structural biology, biology, and screening leaders to define key scientific questions, resolve complex discovery challenges, and recommend priorities. Communicate evidence, uncertainties, and trade-offs to project teams and senior leadership.

Establish and advance hit-finding strategies for novel protein and protein-protein interaction targets, including structure-based and ligand-based virtual screening and the design of diverse chemical libraries.

Guide the evaluation, development, and application of computational methods, including molecular dynamics, enhanced sampling, and free energy calculations. Remain hands-on in solving challenging modeling and molecular design problems.

Collaborate with Advanced Analytics to develop, validate, and apply AI/ML methods that address computational chemistry and drug discovery needs.

Set computational priorities across assigned discovery programs and TQ responsibilities, in alignment with the Head of Computational Chemistry
[…]
anges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

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Base Pay Salary Range
$186,000 — $233,000 USD

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