Senior Manager, Clinical Biomarker Operations

The posting, as Revolution Medicines wrote it

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.

The Opportunity

As a Senior Manager, Clinical Biomarker Operations (CBO) within the Translational Medicine function, you will provide biomarker operational expertise, develop scope of work (SOW), and maintain effective working relationships with cross-functional teams supporting Phase I–III clinical trials.

Operationalize the biomarker program strategies in clinical trials to support early- and late-stage development of portfolio assets.

Lead end-to-end biomarker operations across Phase I–III oncology clinical trials, including protocol reviews, prospective testing strategies, sample lifecycle oversight, data management, query resolution, and vendor qualification and contracting.

Collaborate effectively with biomarker, bioinformatics, and companion diagnostic (CDx) scientists on reviews of protocols, informed consent forms (ICFs), electronic case report forms (eCRFs), data transfer specifications (DTS), Genomic Verification Forms, and electronic trial master file (eTMF) documentation to ensure operational alignment and successful collection and testing of clinical trial samples.

Work closely with biomarker scientists to oversee the development of the statement of work (SOW), budgets, timelines, risk management, and vendor management across all active studies.

Contribute to central laboratory operations, including laboratory startup, review of laboratory manuals and site requisition forms, SOW review, and budget evaluation.

Collaborate cross-functionally with Clinical Development, Clinical Operations, Data Management, Quality Assurance, Regulatory Affairs, Procurement, etc., to ensure operational feasibility and delivery, aligned with clinical trial timelines.

Collaborate with diagnostic partners and internal cross-functional team members to ensure successful management of CDx samples.

Lead biomarker vendor selection, qualification, onboarding, and oversight; participate in vendor audits to assess adherence to regulatory and quality standards; and provide day-to-day operational management to ensure delivery against the contracted SOW.

Collaborate with Clinical Operations and the Biospecimen Management group to manage sample s
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anges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

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Base Pay Salary Range
$164,000 — $205,000 USD

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