Vice President, Clinical Development, Oncology

The posting, as Xaira wrote it

About Xaira Therapeutics

Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets. It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification. Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development. Xaira is headquartered in the San Francisco Bay Area, Seattle, and London.

Position summary

Xaira Therapeutics is seeking a Vice President, Early Clinical Development to lead development of the company’s oncology portfolio as it advances from discovery into the clinic. Reporting to the Senior Vice President, Translational Science and Early Clinical Development, the Vice President will be accountable for clinical development strategy, IND-enabling clinical planning, first-in-human study design and execution, and the progression of priority programs through clinical proof of concept and into late-stage development.

This is a founding clinical development role. The Vice President will establish the clinical development function at Xaira, including its people, operating model, governance, and external network, and will serve as a visible member of the R&D leadership team with influence over portfolio strategy.

Xaira integrates AI, computational biology, and large-scale experimental data across the discovery and development continuum. The Vice President will be expected to apply advanced analytics and model-derived insight to development strategy, trial design, patient selection, and evidence generation, and to exercise disciplined judgment about where these methods add value and where conventional approaches remain the better answer.

Key responsibilities

Clinical development strategy

• Develop and own integrated clinical development plans for priority oncology programs, from development candidate selection through clinical proof of concept and into registrational development.
• Define target product profiles, indication and tumor type strategy, dose and schedule, endpoints, biomarker strategy to inform dose, proof of mechanism and accelerated development opportunities using patient selection approaches with insights from Xaira’s AI platform.
• Translate insight from disease biology, functional genomics, proteomics, computational protein design, and translational studies into clinical hypotheses that can be tested in patients.
• Establish pre-specified go/no-go criteria for each program and make timely, well-reasoned recommendations to advance, redirect, or discontinue.

IND enablement and first-in-human execution

• Lead the clinical strategy and clinical content for IND and CTA submissions, including clinical development plans, first-in-human pro

[…]
opment experience, including regulatory approval of a biomarker-defined indication.

• Experimental medicine, adaptive and model-informed drug development, dose–exposure–response analysis, and seamless Phase 1/2 designs.
• Digital pathology or digital endpoints, causal inference, external control methodology, and real-world oncology data.
• Regulatory experience involving novel analytics, AI-derived biomarkers, digital measures, or non-traditional approaches to evidence generation.
• Prior clinical leadership within an AI-native biotechnology company, a computational drug discovery company, or a pharmaceutical AI and data organization.
• Experience establishing an early clinical development function within a growing organization.

Location and travel

This position is based onsite at Xaira’s South San Francisco headquarters. Travel of approximately [15–25%] is expected for investigator and site engagement, scientific congresses, health authority meetings, and partner interactions.

Compensation
Annual

We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants. We offer a competitive package that includes base salary, bonus, and equity. The base pay range for this position is expected to be $350,000 to $407,000 annually; however, the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience.

Xaira Therapeutics an equal-opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end.

TO ALL RECRUITMENT AGENCIES: Xaira Therapeutics does not accept agency resumes. Please do not forward resumes to our jobs alias or employees. Xaira Therapeutics is not responsible for any fees related to unsolicited resumes.